Aptamers refer to short strands of nucleic acids or peptide molecules
capable of forming secondary and tertiary structures. These molecules bind
specifically to the cellular targets and are created by selecting randomly from
the complex libraries of synthetic nucleic acids. These receptor molecules can
be modified in order to enhance the stability and availability in biological
environments. Aptamers possess potential applications in research, clinical,
industrial and medical areas. Since the 1990s, aptamers have been tested for
their clinical relevance. Aptamers are chemically equivalent to protein
therapeutics and are highly specific, non-immunogenic and small in size.
Despite of its advantages over protein therapeutics, aptamers are not able to
establish their strong presence in the market. According to a research study
published in 2010, till date only one aptamer based drug has received
regulatory approval. The first aptamer based therapeutic was indicated for the
treatment of age related macular degeneration and was FDA approved in the year
2004. At present many other aptamer molecules are being evaluated in clinical
trials.
Emergence of aptamer
molecules in various diagnostic and therapeutic applications holds immense
growth prospects in the near future. With the development of systematic
evolution of ligands by exponential enrichment (SELEX) process, aptamers are
replacing antibodies in both diagnostic and therapeutic applications. Aptamers
market can be categorized on the basis of product type, applications and
geographies. The application areas of aptamers include diagnostics, biosensors,
drug discovery, bio-markers, therapeutics and others. The major product types
of aptamers include nucleic acid and peptide aptamers. High specificity, intensive
research initiatives, wide application areas, technological advancement and
heavy investments by manufacturers are some of the factors driving the growth
of the global aptamers market. Less accessibility, low awareness, stringent
governmental regulations and difficult commercialization of aptamer products
are the major challenges prevalent in this market. Technological advances in
the fields of targeted therapies, nanotechnology and medical imaging facilitate
sustainable growth opportunities for aptamers market. In addition, rigorous
research in pipeline creates the possibility of replacement of antibody
therapies in the near future.
Aptamer Solutions, Ltd,
Aptares AG, AM Biotechnologies LLC, OTC Biotech, Pfizer, Inc., Base Pair
Biotechnologies, Trilink Biotechnologies, Inc. and Aptamer Sciences, Inc. are
some of the leading players in the global aptamers market.
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